Am working on a C# project in Visual Studio revision beta.1925 on Windows 8.1 on a Parallels 11 virtual machine on OSX El Capitan.
Have system set up to do remote debugging (via USB) on a Nexus 10 tablet.
Debug initially works correctly; I can put in breakpoints, examine variables, etc. However, if I make the mistake of doing any code edits while the debugger is paused at a breakpoint, then after I stop the debugger it clears all breakpoints and will no longer set any more. This refusal to set breakpoints is persistent even after a code rebuild. At that point I can run the code in the debugger without breakpoints, but the only way to get the breakpoints to work again is to either 1) close and re-open the project, or 2) close and re-open Visual Studio.
I would post this as fairly low priority bug (a re-start fixes the problem), but it is very easy to forget to shut the debugger down before editing the code, and is annoying to have to periodically restart the project.